Medical Articles and Recommended Reading

Neutropenia
Neutropenia - Chronic
Neutropenia -Congenital
Neutropenia -Cyclic
Neutropenia - Idiopathic
Neutropenia - Autoimmune
Neutropenia - Neonatal
MDS/AML
G-CSF
Shwachman-Diamond Syndrome
Anemia
Myelokathexis
Granulocytopenia
Misc.


Neutropenia

Weetman RM, Boxer LA, Childhood neutropenia. Pediatric Clinics of North America 1980; 27:361-376.

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Neutropenia - Chronic

Pincus SH, Boxer LA, Stossel TP. Chronic neutropenia in childhood: Analysis of 16 cases and review of the linterature. American Journal of Medicine 1976; 61:849-861.

Boxer L, Dale D, Bonilla MA, Cham B, Freedman MH, Kannourakis G, Brown S, Fier C, Welte K: Administration of r-metHuG-CSF during pregnancy in patients with severe chronic neutropenia (SCN) [abstract] Blood 1995, 86 (suppl 1):508.

Dale DC, Cottle T, Bolyard AA, Fier C, Bonilla MA, Boxer L, Brown SL, Cham B, Freedman MH, Kannourakis G, Welte K: Severe chronic neutropenia: report on treatment and outcome from a new international registry [abstract] Blood 1995, 86(suppl1):425

Boxer L, Bonilla MA, Cham B, Freedman MH, Kannourakis G, Brown S, Fier C, Welte K, Dale D: Severe chronic neutropenia: from the laboratory to the clinic [abstract] Int Hematol 1996, 64(suppl 1):59.

Dale DC, Bonilla MA, Davis MW, Nakanishi AM, Hammond WP, Jurtzberg J, Wang W, Jakubowski A, Winton E, Lalezari P, Robinson W, Glaspy JA, Emerson S, Gabrilove J, Bincent M, Boxer LA: A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia. Blood 1993, 81:2496-2502.

Kannourakis G, Kirtzberg J, Bonilla MA, Boxer L, Catalano P, Cham B, Fier C, Kinsey S, Marty J, Freeman MH, Mori PG, Thompson B, Dale DC, Welte K: Report on patients with glycogen storage disease 1b with severe chronic neutropenia treated with filgrastim [abstract]. Blood 1996, 88(suppl 1):349

Zeidler C, Bonilla MA, Boxer L, Catalano P, Cham B, Fier C, Freedman MH, Kannourakis G, Kinsey S, Mori PG, Dale DC, Welte K: Report on patients with severe chronic neutropenia refractory to G-CSF [abstract]. Blood 1996, 88(suppl 1):349

Fazio MT, Glaspy JA: The impact of granulocyte colony-stimulating factor on quality of life in patients with sever chronic neutropenia. Oncol Nurs Forum 1991, 18:1411-1414.

Jones E, Bolyard A, Dale DC. Effect of granulocyte colony-stimulating factor on quality of life in patients with severe chronic neutropenia. Clinical Research 1993, 41:65a.

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Neutropenia -Congenital

Welte k, Zeidler C, Reiter A, Muller W, Odenwald E, Souza L, Reihm H: Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia. Blood 1990, 75:1056-1063.

Dong F, Dale DC, Bonilla MA, Freedman M, Fasth A, Nejijens HJ, Palmblad GL, Carlsson BG, Veerman AJP, Welte K, Lowenberg B, Touw IP: Mutations in the granulocyte-colony stimulating factor receptor gene in patients with severe congenital neutropenia, Leukemia 1997, in press.

Lightsey AL, Parmley RT, Marsh WL et al. Severe congenital neutropenia with unique features of dysgranulopoiesis. American Journal of Hamatology 1985, 18:59-71.

Bonilla MA, Dale DC, Zeidler C, Last L, Reiter A, Ruggeiro M, Davis M, Koci B, Hammond W, Gillio A, Welte K: Long-term safety of treatment with recombinant human granulocyte colony-stimulating factor (rmetHuG-CSF) in patients with severe congenital neutropenias. British Journal of Haematology, 1994, 88:723-730.

Kalra R, Dale D, Freedman M, Bonilla MA, Weinblatt M, Ganser A, Bowman P, Abish S, Priest J, Oseas RS, Olson K, Paderanga D, Shannon K: Monosomy 7 and activating ras mutations accompany malignant transformation in patients with congenital neutropenia. Blood 1995, 86:4579-4586.

Dong F, Brynes RK, Tidow N, Welte K, Lowenberg B, Touw IP: Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. New England Journal of Medicine 1995, 333:487-492.

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Neutropenia -Cyclic

Williams DM, Jones JV Jr. Lithium carbonate treatment in familial cyclic neutropenia. American Journal of Chonical Pathology 1984: 81:120-122.

Hammond WP, Berman B, Wright DG, Dale DC. Lithium is an ineffective therapy for human cyclic neutropenia. Blood 1983. 61:1024-1026.

Hammond WP, Chatta GS, Andrews RG, Dale DC: Abnormal responsiveness of granulocyte-committed progenitor cells in cyclic neutropenia. Blood 1992, 79:2536-2539.

Hammond WP, Price TH, Souza LM, Dale DC: Treatment of cyclic neutropenia with granulocyte colony-stimulating factor. New England Journal of Medicine. 1989, 320:1306-1311.

Dale DC, Hammond WP: Cyclic Neutropenia A clinical review. Blood Reviews 1988, 2:178-185.

Morley AA, Carew JP, Baikie AG. Familial cyclical neutropenia. British Jounal of Haematology 1967; 113:719-737.

Wright DG, Dale DC, Fauci AS, Wolff SM, Human cyclic neutropenia: Clinical review and long-term follow-up of patients Medicine 1981, 60:1-13.

Lange RD. Cyclic hematopoiesis: Human cyclic neutropenia. Experimental Hematology 1983, 11:435-451.

Page GR, Good RA. Studies on cyclic neutropenia. American Journal of Diseases in Childhood 1957 , 94:623-661.

Guerry D, Dale DC, Omine M, Perry S, Wolff SM. Periodic hematopoiesis in human cyclic neutropenia. Journal of Clinical Investigation 1973, 52:3220-3230.

Wright DG, Fauci AS, Dale DC, Wolff SM. Correction of human cyclic neutropenia with prednisone. New England Journal of Medicine 1978, 298:295-300.

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Neutropenia - Idiopathic

Browne EA, Marcus AJ. Chronic idiopathic neutropenia: A newly recognized entity? New England Journal of Medicine 1960, 262:795-798.

Logue GL, Shastri KA, Laughlin M et al. Idiopathic neutropenia: Antineutrophil antibodies and clinical correlations. American Journal of Medicine 1991, 90:211-216.

Van der Veen JPW, Hack CE, Engelfriet JG et al. Chronic idiopathic and secondary neutropenia: clinical and serological investigations. British Journal of Haematology 1986, 63:161-171.

Lipton A. Chronic idiopathic neutropenia: Treatment with corticosteroids and mercaptopurine. Archives of Internal Medicine 1969, 123:694-700.

Kyle RA. Natural history of chronic idiopathic neutropenia. New England Journal of Medicine 1980, 302:908-909.

Jakubowski AA, Souza L, Kelly F, Fain K, Budman D, Clarkson B, Bonilla MA, Moore MAS, Gabrilove J: Effects of human granulocyte colony-stimulating factor in a patient with idiopathic neutropenia. New England Journal of Medicine 1989, 320:38-42.

Freund M, Heussner P, Scandoval M: Granulocyte colony-stimulating factor (G-CSF) for the treatment of adult patients with chronic idiopathic neutropenia and cyclic neutropenia. Onkologie 1991, 2:43-44.

Furukawa T, Takahashi M, Moriyama Y, Koike T, Kurokawa I, Shibata A: Successful treatment of chronic idiopathic neutropenia using recombinant granulocyte-colony-stimulating factor. Ann Hematology 1991, 62:22-24.

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Neutropenia - Autoimmune

Boxer LA, Greenberg MS, Box GJ, Stossel TP. Autoimmune neutropenia. New England Jounal of Medicine 1975, 293:748-753.

Lalezari P, Khorshidi M, Petrosova M. Autoimmune neutropenia of infancy. Journal of Pediatrics 1986, 109:764-768.

Bussel JB, Abboud MR. Autoimmune neutropenia of childhood. Critical Reviews of Oncology and Hematology 1987, 7:37-51.

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Neutropenia - Neonatal

Lalezari P, Murphy GB, Allen FH Jr. BN1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia. Journal of Clinical Investigation 1971, 50:1108-1115

Lalexari P, Nussbaum M, Gelman S, Spaet TH. Neonatal neutropenia due to maternal isoimmunization. Blood 1960, 15:236-243.

Boxer LA, Yokoyama M, Lalexari P. Isoimmune neonatal neutropenia. Journal of Pediatrics 1972, 80:783-787.

Lalezari P, Bernard GE. An isologous antigen-antibody reaction with human neutrophils, related to neonatal neutropenia. Journal of Clinical Investigation 1971, 50:1108-1115.

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MDS/AML

Melvin H. Freedman, Mary Ann Bonilla, Carol Fier, Audrey Anna Bolyard, Debra Scarlata, Laurence A. Boxer, Sherri Brown, Bonnie Cham, George Kannourakis, Sally E. Kinsey, Pier Georgio Mori, Tammy Cottle, Karl Welte, and David C. Dale, Myelodysplasia syndrome and acute myeloid leukemia in patients with congenital neutropenia receiving G-CSF therapy:  Article in Blood, 15 July 2000: Volume 96, Number 2

Tanya Bernard, Rosemary E. Gale, Jane P. M. Evans* and David C. Linch Departments of Haematology.  University College London Medical School and *Great Ormond Street Hospital, London, Mutations of the granulocyte-colony stimulating factor receptor in patients with severe congenital neutropenia are not required for transformation to acute myeloid leukaemia and may be a bystander phenomenon:  British Journal of Haematology, 1998, 101, 141-149.

Sima Jeha, Ka Wah Chan, Andrew G. Aprikyan, W. Keith Hoots, Steven Culbert, Hallie Zietz, David C. Dale, and Maher Albitar, Spontaneous remission of granulocyte colony-stimulating factor-associated leukemia in a child with severe congenital neutropenia, Article in Blood, 15 November 2000: Volume 96, Number 10.

Kazuko Kudo-1, Hirokazu Nagai-2, Shin-Ichiro Numata-3, Masatoshi Ichihara-4,Tomohiro Kinoshita-2,Keizo Horibe-5, Koji Kato-1,Takaharu Matsuyama-1,Yoshihisa Kodera-6 and Seiji Kojima-5, 1-Division of Haematology/Oncology, Children's Medical Centre, Japanese Red Cross Nagoya First Hospital, 2-The First Department of Internal Medicine, 3-Department of Biochemistry II, 4-Department of Pathology, 5-Department of Developmental Paediatrics and Department of Paediatrics, Nagoya University School of Medicine, and 6-Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan, Absence of mutations in the granulocyte colony-stimulating factor (G-CSF) receptor gene in patients with myelodysplastic syndrome/acute myeloblastic leukaemia occurring after treatment of aplastic anaemia with G-CSF, British Journal of Haematology, 2000, 111, 656-658.

Dale D, Bonilla MA, Boxer L, Freedman M, Brown S, Fier C, Welte K: Development of AML/MDS in a subset of patients (PTS) with severe chronic neutropenia (SCN) [abstract] Blood 1994, 84 (suppl1):518.

Freedman MH, Bonilla MA, Boxer L, Catalano P, Fier C, Kannourakis G, Kinsey S, Mori PG, Sannon K, Touw I, Welte K, Dale DC: MDS/AML in patients with severe chronic neutropenia receiving G-CSF [abstract] Blood 1996 88(suppl 1):448.


G-CSF

Welte KE, Platzer E, Lu L, Gabrilove J, Mertelsmann R, Moore MAS: Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci USA 1985, 82:1526-1530.

Zsebo KM, Cohen AM, Murdock DC, Boone TC, Inoue H, Chazin VR, Hines D, Souza LM: Recombinant granulocyte colony stimulating factor: molecular and biological characterization. Immunobiology 1986, 172:175-184.

Souza LM, Boone TC, Gabrilove J, Lai PH, Zsebo KM, Murdock DC, Chazin VR, Bruszewski J, Lu H, Chen KK, Barendt J, Platzer E, Moore MAS, Mertelsmann R, Welte K: Recombinant human granulocyte colony stimulating factor: effects on normal and leukemic myeloid cells. Science 1986, 232:61-65.

Molineaux G, Dexter TM: Biology of G-CSF, In Filgrastim (r-metHuG-CSF) in Clinical Practice. Edited by Morstyn G, Dexter TM. New York: Marcel Dekker; 1994:1-21.

Chang JM, Metcalf D, Gonda TJ, Johnson GR: Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a noneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice. J Clin Invest 1989, 84:1488-1496.

Pojda Z, Molineaux G, Dexter TM: Hemopoietic effects of short-term in vivo treatment of mice with various doses of rhG-CSF. Exp Hematol 1990, 18:27-31.

Bonilla MA, Gillio AP, Ruggeiro M, Kernan NA, Brochstein JA, Abboud M, Fumagalli L, Vincent M, Gabrilove JL, Welte K, Souza LM, O’Reilly RJ: Effects of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with congenital agranulocytosis. New England Journal of Medicine 1989, 320:1574-1580.

Decoster G, Rich W, Brown SL: Safety profile of filgrastim (r-metHuG-CSF). In Filgrastim (r-metHuG-CSF) in Clinical Practice. Edited by Morstyn G, Dexter TM. New York: Marcel Dekker, 1994:267-290.

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Shwachman-Diamond Syndrome

Mack DR, Forstner GG, Wilschanski M, Freedman MH, Durie PR: Shwachman syndrome: exocrine pancreatic dysfunction and variable phenotypic expression. Gastroenterology 1996, 111:1593-1602.

Smith OP, Hann IM, Chessels JM, Reeves BR, Milla P: Haematological abnormalities in Shwachman-Diamond syndrome. Brithish Journal of Haematology 1996, 94:279-284.

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Anemia

Rackoff WR, Orazi A, Robinson CA, Cooper RJ, Alter BP, Freedman MH, Harris RE, Williams DA: Prolonged administration of granulocyte colony-stimulating factor (filgrastim) to patients with Fanconi anemia: a pilot study. Blood 1996, 88:1588-1593.

Alter BP, Scalise A, McCombs J, Najfeld V: Clonal chromosomal abnormalities in Fanconi’s anaemia: what do they really mean? British Journal of Haematology 1993, 85:627-630.

Kojima S, Tsuchida M, Matsuyama T: Myelodysplasia and leukemia after treatment of aplastic anemia with G-CSF [letter] New England Journal of Medicine 1992, 326:1294-1295.

Sonoda Y, Ohno Y, Fujii H, Takahashi T, Nakayama S, Haruyama H, Nasu K, Shimazaki C, Hara H, Kanamaru A, Kakishita E, Horiuchi A, Abe T, Masaoka T, Uchino H, Nagai K: Multilineage response in aplastic anemia patients following long-term administration of filgrastim(G-CSF). Stem Cells 1993, 11:543-554.

Sonoda Y, Yashige H, Fujii H, Tsuda S, Maekawa T, Misawa S, Abe T: Bilineage response in refractory aplastic anemia patients following long-term administration of recombinant human granulocyte colony-stimulating factor. European Journal of Haematology 1992, 48:41-48.

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Myelokathexis

Bassan R, Viero P, Minetti B, Comotti B, Barbui T. Myelokathexis: A rare form of chronic benign granulocytopenia. British Journal of Haematology 1984, 58:115-117.

Bohinjec J. Myelokathexis: chronic neutropenia with hyperplastic bone marrow and hypersegmented neutrophils in two siblings. Blut 1981, 42:191-196.

Plebani A, Cantu-Rajnoldi A, Collo G et al. Myelokathexis associated with multiple congenital malformations: immunological study on phagocytic cells and lymphocytes. European Journal of Haematology 1988, 40:12-17.

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Granulocytopenia

Krill CE, Smith HD, Mauer AM. Chronic idiopathic granulocytopenia. New England Journal of Medicine 1964, 270:973-978.

Zuelzer WW, Bajoghli M. Chronic granulocytopenia in childhood. Blood 1964, 23:359-374.

Vahlquist B, Anjou N. Granulocytopenie chronique benigne. Acta Haematologica 1952, 8:199-208.